Native Chicken Sternal Collagen type 2 for joint Health
| Material name | Undenatured Chicken Collagen type ii for Joint Health |
| Origin of material | Chicken sternum |
| Appearance | White to slight yellow powder |
| Production process | Low temperature hydrolyzed process |
| Undenatured type ii collagen | ＞10% |
| Total protein content | 60% (Kjeldahl method) |
| Moisture content | ≤10% (105°for 4 hours) |
| Bulk density | ＞0.5g/ml as bulk density |
| Solubility | Good solubility into water |
| Application | To produce Joint care supplements |
| Shelf Life | 2 years from production date |
| Packing | Inner packing: Sealed PE bags |
| Outer packing: 25kg/Drum |
Active chicken sternal Collagen Type II is a functional ingredient for the maintenance of body flexibility. It mainly uses non-denatured Type II collagen extracted from chicken breast cartilage at low temperature. Because of the special extraction technology, the protein still retains the triple helix structure, which is more biologically beneficial.
In scientific experiments, it was found that after entering the intestinal tract, Native collagen type 2 can initiate a special desensitization process, also known as "oral immune tolerance". The process can train immune cells to identify the correct cartilage protein molecules in the tissue. In turn, it prevents the inflammatory response and destructive attack, which is the main cause of joint stiffness and pain in general, and has the benefit of relieving joint discomfort.
| PARAMETER | SPECIFICATIONS |
| Appearance | White to off white powder |
| Total Protein Content | 50%-70% (Kjeldahl Method） |
| Undenatured Collagen type II | ≥10.0% (Elisa Method） |
| Mucopolysaccharide | No less than 10% |
| pH | 5.5-7.5 (EP 2.2.3) |
| Residual on Ignition | ≤10%(EP 2.4.14 ) |
| Loss on drying | ≤10.0% (EP2.2.32) |
| Heavy Metal | ＜ 20 PPM(EP2.4.8) |
| Lead | ＜1.0mg/kg( EP2.4.8) |
| Mercury | ＜0.1mg/kg( EP2.4.8) |
| Cadmium | ＜1.0mg/kg( EP2.4.8) |
| Arsenic | ＜0.1mg/kg( EP2.4.8) |
| Total Bacteria Count | ＜1000cfu/g(EP.2.2.13) |
| Yeast & Mold | ＜100cfu/g(EP.2.2.12) |
| E.Coli | Absence/g (EP.2.2.13) |
| Salmonella | Absence/25g (EP.2.2.13) |
| Staphylococcus aureus | Absence/g (EP.2.2.13) |
The difference between "denatured" and "non-denatured" is that once collagen is hydrolyzed by high temperature and acid, it loses its original protein structure, which is called "denaturation".
On the other hand, if it is extracted at low temperature, the triple-helix three-dimensional structure of collagen will be preserved, and it will become "non-deformable" because the protein structure is more complete and can maintain better biological utilization rate.
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Native Chicken Collagen type 2 |
Denatured type ii collagen |
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| Key Feature | Active collagen in original triple helix structure | Denatured without any activity |
| Manufacturing process | Low temperature production process to maintain the structure of collagen | High temperature production process |
| Price | High | Different origins with different prices |
The scientific study proves that the Undenatured chicken collagen type ii provides benefits for joint health. The clinical study on the animals proves that benefits of Undenatured type ii chicken collagen are confirmed in trials of traumatic osteoarthritis, post-traumatic and obesity-induced arthritis of rats.
In the post-traumatic osteoarthritis trial, joint damage resulted in the loss of cartilage (matrix and chondrocytes) and severe local inflammation of the knee joint. After taking low-dose Active Collagen II, the following benefits were clearly proved:
1. Prevent Cartilage Degradation and Lubrication
Undenatured chicken collagen type ii can protect cartilage and reduce degenerative changes (normalization of chondroitin region, blue bars on the left side of the diagram below), stimulates proteoglycan synthesis in chondrocytes and promotes joint lubrication (the percentage of activated chondrocytes increases, as shown in the blue histogram on the right side of the diagram below).
Diagram No.1: Undenatured Chicken Collagen type ii Prevents cartilage degradation and promotes the synthesis of lubricating matrices.
1. Reduce the inflammation
Undenatured chicken collagen type ii promotes the anti-inflammatory effect of knee joints (reduces the expression of local inflammatory markers in the synovial membrane, See blue histogram in below diagram).
Diagram No.2: Undenatured chicken collagen type ii reduces the inflammation of OA.
2. Prevent OA (Osteoarthritis)
In the obese and traumatic osteoarthritis trial, the loss of knee joint cartilage (matrix and chondrocytes) and the local inflammatory response were transiently induced. Low-dose
Undenatured chicken collagen type ii supplementation can prevent osteoarthritis in below aspects:
Experiments on mice that are obese by high-fat diets have shown protection of cartilage, reduction of degenerative changes (Cartilage zone normalization, blue histogram on the left side of the diagram below), and promotion of joint lubrication by stimulating proteoglycan synthesis in chondrocytes. (The percentage of activated chondrocytes increases, the blue histogram on the right side of the diagram below).
Diagram No.3 : Undenatured chicken Collagen type ii prevents the degradation of cartilage and promotes the synthesis of a lubricating matrix in the osteoarthritis caused by obesity.
3. High bioavailability
The study shows that 1 hour after taking Undenatured type ii the hydroxyproline in mouse serum reaches a high concentration, which proves that Undenatured chicken type ii has a high bioavailability.
Packing: Our packing is 25KG/Drum for big commercial orders. For small quantity order, we can do packing like 1KG,5KG, or 10KG, 15KG in a Aluminum foil bags.
Sample Policy: We can provide up to 30 grams free of charge. We usually send the samples via DHL, if you have a DHL account, please kindly share with us.
Price: We will quote the prices based on different specifications and quantities.
Custom Service: We have dedicated sales team to deal with your inquiries. We promise you will sure get a response within 24 hours since you send a inquiry.
